Furthermore, APOB is positively correlated with secreted protein acidic and rich in cysteine (SPARC) [71], which expression is frequently associated with the excessive deposition of collagen [72] and in BC, SPARC could promote TGF-β-induced epithelial-mesenchymal transition (EMT), and further promote the tumor metastasis [73]. Here, TGFB1 is linked to breast cancer.