TGFB1 and neoplasm: Then, we detected the levels of TGF-β and hypoxia in mice tumor through a series of strict controls, including the up-regulation of TGF-β and hypoxia stimulation of oxygen rich tumors (‘T1’) as well as the down-regulation of TGF-β and oxygen supply to hypoxic tumors (‘T2’), and analyzed the mutual regulation relationship between TGF-β and hypoxia.