FBXW7 and neoplasm: Although, cancer cells are known to evade apoptosis through a variety of mechanisms, it is already established that these tumour-associated circulating lncRNAs are released in the extra-cellular space by tumour cells along with protective lipids and proteins, RNA-binding proteins, neucleophosmin (NPM1), Argonaute (AGO) proteins, high density lipoproteins, or sometimes without any binding partner within the exosome vesicles to avoid nuclease activity when they are in circulation [11].