TP53 and endometrial cancer: The Cancer Genome Atlas (TCGA) project proposed four groups of endometrial cancer ranging from good to poor prognoses: (1) POLE-mutated (POLEmut); (2) hyper-mutated “MSI”; (3) low copy number “NSMP;” and (4) a high number of copies “TP53 mutated” (serous-like) [26].In addition to the excellent prognostic value of the TCGA molecular classification shown for UCEC, deep myometrial invasion (DMI) has been considered a crucial risk factor and influenced the risk of recurrence independently from the TCGA groups [27].