When we examined pro-tumoral cytokines, such as IL-2 and IL-4, we found that a high colorectal cancer PRS was associated with high IL2 score 21,050,467 (1.09; 1.004–1.18; p = 0.0434) and IL-4 score 21,050,467 (1.12; 1.03–1.21; p = 0.0116) levels in the early stages. This evidence concerns the gene IL4 and colorectal cancer.