When different tumour stages (TNM classification) [41] were compared, a significant difference in CSPG4 expression was observed between early (Stage I & II) and late stage (Stage III & IV) HNSCCs; with lower expression in local and distal metastatic stages (III & IV) (by one-way ANOVA, α = 0.05, p = 0.0277) (Figure 5b). The gene discussed is CSPG4; the disease is neoplasm.