CSPG4 and recessive dystrophic epidermolysis bullosa: In addition, recent transcriptome re-analysis of cell lines and tissues from the rare RDEB population, where SCC diagnosis is almost always lethal, showed that CSPG4 expression is significantly higher in RDEB cSCCs than in RDEB skin [43,145] (p = 0.0031, by ANOVA, α = 0.05) (Figure 4a).