SULF2 and neoplasm: However, SULF1 and SULF2 mRNAs are >20-fold higher in the PDAC tumor tissues than in the non-disease pancreatic tissue from the GTEx (SULF1 log2FC = 6.81, SULF2 log2FC = 4.85, both p < 0.001, Figure 1D), which is consistent with the large difference in the protein expression (Table 2).