SULF2 and neoplasm: The mean SULF1 mRNA, represented as log2(TPM+1), is 0.172 in tumor cells compared with 1.099 in fibroblasts (p < 0.001); the mean value of SULF2 mRNA is 1.145 in tumor cells compared with 0.386 in fibroblasts (p < 0.001) (Figure 4A).