Furthermore, A protein panel for early detection of CRC was discovered by Bhardwaj et al. [109], by using liquid chromatography/multiple reaction monitoring-mass spectrometry in plasma samples from 96 CRC patients, and 94 controls, using a blood-based profile of five markers, osteopontin, serum paraoxonase lactonase 3, transferrin receptor protein 1, mannan-binding lectin serine protease 1, and amphiregulin. This evidence concerns the gene AREG and colorectal carcinoma.