CXCL1 and colorectal carcinoma: CXCL-1 (C-X-C motif ligand 1) and CXCL-8 (C-X-C motif ligand 8) and their receptors have also demonstrated a potential role as biomarkers for CRC prognosis and diagnosis [115], Pczek S et al. conducted a study in which increased levels of CXCL-8 were found in CRC patients when compared to normal subjects.