Additionally, a number of members of the Serpin family including SERPINC1 (antithrombin-3, AT-III), SERPINA3 (alpha-1 antichymotrypsin, AACT), and SERPINA1 (alpha-1 antitrypsin, A1AT), have been identified as potential biomarkers for colorectal carcinoma and adenomatous polyps by using multiplexed quantification isobaric tags for absolute and relative quantitation (iTRAQ), [110]. This evidence concerns the gene SERPINC1 and colorectal carcinoma.