Overall, most biomarkers were upregulated in cancers such as PAAD, stomach adenocarcinoma (STAD), Esophageal carcinoma, (ESCA), head and neck squamous cell carcinoma (HNSC), whereas only a few biomarkers were upregulated in prostate adenocarcinoma (PRAD; NXPH4, AGR2, MMP10), breast invasive carcinoma (BRCA; COL3A1, MMP1, AGR2), bladder urothelial carcinoma (BLCA; MMP1, NXPH4), thyroid carcinoma (THCA; LCN2, AGR2) (Figure 4A). The gene discussed is NXPH4; the disease is cancer.