AKT1 and urinary bladder carcinoma: In addition, Kavalactones (yangonin, flavokawain A, and docetaxel), are a class of lactone compounds present in the roots of kava (Piper methysticum Forst), capable of inhibiting the mTOR pathway by changing the upstream (LKB1, AKT signaling, and PRAS40) and downstream (rpS6, p70S6K, and 4EBP1) events of the mTOR pathway, consistent with reduced viability of human bladder cancer cell lines [207].