RPS6KB1 and cervical squamous cell carcinoma: In another study by Feng et al., morphoproteomic assays indicate constitutive activation and predominant overexpression of the mTOR pathway in both squamous intraepithelial lesions of high grade and cervical squamous cell carcinomas, as demonstrated by enhanced translocation of nuclear pmTOR and p-p70S6K, which are phosphorylated at putative activation sites, Ser2448 and Thr389, respectively.