Furthermore, immunohistochemical analysis of prostate cancer adenocarcinoma revealed that more than 90% of the cases detected the phosphorylated form of AKT of samples and correlated with high Gleason grade of prostate cancer, confirming that aberrant activation of the PI3K/AKT/mTOR pathway is associated with the progression of prostate cancer [179]. This evidence concerns the gene MTOR and Familial prostate cancer.