It is well documented that curcumin acts against cancer by altering multiple cellular targets and a broad set of signal transduction pathways, including up-regulation of toxic intracellular ROS release, induction of apoptotic cell death, modulation of microRNAs, cell cycle arrest, and regulation of various protein kinases cascades as well as NF-ĸB and p53 signaling pathways [42]. Here, TP53 is linked to cancer.