Experiments performed in in vivo models show that a long-term dietary consumption of hydroxylated PMFs resulted in the reduction of colon cancer cell proliferation and inhibition of the inflammation through the downregulation of Wnt/β-catenin and EGFR signaling pathways as well as the activation of STAT3 and NF-kB transcription factors, thus blocking the expression of iNOS, COX-2 VEGF and MMP-9 [172]. This evidence concerns the gene PTGS2 and colonic neoplasm.