Limonin and limonin glucoside isolated from seeds of Citrus reticulata inhibit the colon cancer cell proliferation inducing the cell cycle block in G0/G1 phase, suppressing the CDK4/6 and cyclin D3 expression and inducing the apoptosis, through the DNA fragmentation and the activation of caspase-3 [173]. This evidence concerns the gene CASP3 and malignant colon neoplasm.