Moreover, their impact in the receptor tyrosine kinase signaling (e.g., EGFR, IGFR, VEGF, or nerve growth factor (NGF) receptors) warrants further investigations, because of the role of these receptors and their intersection with the so-called nuclear receptors in many human proliferative diseases, including breast, prostate, and colon cancers [206,207,208,209,210,211]. The gene discussed is IGF1R; the disease is colonic neoplasm.