BRAF and metastatic colorectal cancer: According to major guidelines, the preferred option as first-line treatment for patients with unresectable left-sided RAS and BRAF wild-type metastatic colorectal cancer (mCRC) is represented by a cytotoxic fluoropyrimidine-based doublet (FOLFOX or FOLFIRI) in association with an Anti-epidermal growth factor receptor monoclonal antibody (i.e., EGFRi, cetuximab, or panitumumab) [3,4].