Five macrophage clusters (RTM_1-RTM_4) were consistent with the features of resident macrophages previously reported [3], including a high expression of MHCII (e.g., HLA-DMB, HLA-DRB5, HLA-DQA1, HLA-DOB, HLA-DPB1, HLA-DPA1, etc.), CD11b/ITGAM, and MRC1 (Figure 1D,E, and Figure S1B), and were denoted as RTMs, whereas the remaining clusters were denoted as tumor-associated macrophages (TAM_1-TAM_5). Here, HLA-DQA1 is linked to neoplasm.