It is well known that CD4+ T cells are involved in NAFLD-related inflammation and fibrosis, however, the role of each CD4+ Th cell subset in the onset and progression of the disease is different, for instance, Th1 cells are thought to be profibrotic while Treg cells are thought to be antifibrotic [14,15,16]. Here, CD4 is linked to metabolic dysfunction-associated steatotic liver disease.