At the same time, PSME1 expression was associated with the improvement of ES patient survival (Log-rank test, p = 0.031), and COL6A2 and FLNC (Figure 5A) showed a negative impact on the survival of ES patients (Log-rank test, p = 0.046, and p = 0.035 relatively), and involvement in the regulation of integrin and ERK pathways (www.genecards.com (accessed on 1 February 2021)). The gene discussed is FLNC; the disease is Ewing sarcoma.