TP53 and cancer: Curcumin also works on several other cancers such as glioblastoma by acting through MMP, NF-κB, STAT3, and PI3K/Ak/mTOR downregulation [87]; breast cancer by p53 regulation [88], and lung cancer metastasis inhibition by regulating the adiponectin/NF-κB/MMPs signaling pathway [89].