For example, Lactobacillus plantarum (LPCLA) induced apoptosis in breast cancer cells by downregulating the NF-κB pathway, while other bacteria such as Lactobacillus crispatus and L. rhamnosus modulated the pro-oncogenic Wnt/β-catenin pathway in various cancer cell lines [231,232]. This evidence concerns the gene NFKB1 and breast cancer.