GNAS and colorectal carcinoma: On the grading of GNAS gene mutation in CRC, “Well graded” recorded the highest GNAS gene mutation of 57.5% (95% CI: 0.324–0.792) while the “Moderately graded” has the least prevalence value of 10.7% (95% CI: 0.033–0.296) (Table 2; Figure S4, S5, S6, S7, S8 and S9 respectively).