Just as with the KRAS, the GNAS gene mutations are frequently detected in lots of tumour types, detected in about 5% of all sequenced malignant tumours, as well as 4–7% in colorectal cancers (CRCs) [4], 41% in intraductal papillary neoplasms of the pancreas [7] and about 15% in liver cancer [8]. Here, GNAS is linked to colorectal cancer.