TFF1 and neoplasm: Comparing with the adjacent normal tissues, it was identified that TFF1 and TFF2 were both downregulated in tumor tissues, which is similar to the previous studies [27] Through the Kaplan–Meier survival analysis based on TCGA database, we found out that high TFF1/TFF2 expressed cohort showed an advantage in OS and TFS as compared to TFF1/TFF2 low expressed cohort.