Bifidobacterium such as Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium pseudocatenulatum, Bifidobacterium longum, and Bifidobacterium dentium have benefits in T2DM and can improve host glucose tolerance and glucose-induced insulin secretion as well as reduce inflammation [35]. Here, INS is linked to type 2 diabetes mellitus.