The Tau/Cre (Mg/Cre) ratio was significantly inversely associated with obesity, hypercholesterolemia, and hypertension (P for linear trend < 0.001 for the association of the Mg/Cre ratio with obesity, hypercholesterolemia, and hypertension and for the association of the Tau/Cre ratio with obesity and hypercholesterolemia, and <0.05 for the association of the Tau/Cre ratio with hypertension). The gene discussed is MAPT; the disease is Hypercholesterolemia.