BRAF and melanoma: Cutaneous melanomas are classified into four subtypes: (i) mutation of the B-Raf proto-oncogene serine/threonine kinase (BRAFmut), (ii) mutation of the NRAS proto-oncogene GTPase (NRASmut), (iii) mutation of neurofibromin 1 (NF1mut), and (iv) none of the three, triple BRAF/NRAS/NF1 wild-type (WT) [3,4,5].