Several studies have shown that adiponectin could induce cell growth in ER-positive breast cancer through the MAPK activating signaling pathway, thus behaving as a growth factor in ERα-positive breast cancer cells, which suggested the importance of ER status in breast tumorigenesis and the capacity of this pathway to modulate the effect of adiponectin on cell metabolism [71]. The gene discussed is ADIPOQ; the disease is breast cancer.