AdipoRon exhibits an adiponectin-like effect in multiple health conditions including obesity [112], diabetes [113], cardiac fibrosis [114], neuroinflammation and depression [115], liver inflammation [116], and dermal fibrosis [117], in addition to its anti-proliferative effect against several cancers including pancreatic cancer [100,102], ovarian cancer [103], osteosarcoma [105], and myeloma [104]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.