ADIPOQ and obesity due to melanocortin 4 receptor deficiency: A clinical study that included 25 breast cancer patients with hereditary breast cancer syndrome and 38 healthy relatives showed that in the healthy group, the mutated BRCA carriers have significantly higher adiponectin levels than BRCA wild-type healthy subjects, which confirms that obesity is an important risk factor for hereditary breast cancer and suggests that adiponectin has exhibited a suppressive effect on carcinogenesis in hereditary breast cancer [70].