Ujfaludi et al. (2022) analyzed the transcriptomic signature of key ccRCC driver genes, VHL, SETD2, PBRM1, and BAP1, to find that the median transcription of these genes distinguished ccRCC from normal tissue with a moderate level of sensitivity and specificity (87% and 77%, respectively) [44]. This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.