These channels are highly expressed in GBM cells [22] and are heteromeric channels made of the protein leucine-rich repeat containing 8A (LRRC8A) and at least one other LRRC8 isoform among LRRC8B, LRRC8C, LRRC8D and LRRC8E [23]. Here, LRRC8A is linked to glioblastoma.