In this study, we conducted a database search and found that two other tumor suppressor genes, NOTCH1 and FAT1, have a high nonsense mutation rate (NOTCH1: 19.62% and FAT1: 40.11%) in HNSCC mutation samples in the COSMIC database compared to other cancers (Figure 1B,C) [21]. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.