Although experimental overexpression of IL-27 in the micromilieu of colon cancer resulted in decreased tumor growth even in the absence of IL-12p40, the functional repertoire of IL-27 also includes effects that could only be observed as synergistic effects together with IL-12, such as, for instance, the enhancement of IFNγ production in CD8+ T cells [118]. Here, CD8A is linked to colonic neoplasm.