In addition to its direct anti-proliferative impact on colon tumor cells [62] and its capacity to inhibit tumor-associated angiogenesis [63], IFNγ particularly supports the immune cell-driven tumor defense, including the MHC-I- and MHC-II-dependent presentation of tumor antigens and the activation, expansion, and survival of tumor-infiltrating effector T cells [13,64]. This evidence concerns the gene IFNG and colonic neoplasm.