CD8A and colonic neoplasm: Indeed, the intratumoral delivery of lipid nanoparticle-encapsulated IL-12p70 mRNA resulted in the increased secretion of IL-12p70 protein by the colon tumor cells and, subsequently, resulted in a Th1 shift in the tumor microenvironment, triggering IFNγ -driven and CD8+ T cell-dependent antitumor immunity [116].