In this context, it is noteworthy that a recent study pointed to the histone methyltransferase WHSC1 as an essential mediator of the IFNγ-promoted MHC-I expression in colon cancer cells, whose capacity to epigenetically modulate gene transcription did not seem to be involved in the IFNγ-induced expression of PD-L1. The gene discussed is NSD2; the disease is colonic neoplasm.