Regarding the impact of CXCL11 on the different Th cell subtypes, its presence in CRC did not correlate with the accumulation of FoxP3+ Treg cells and additionally performed transcriptional analyses implicated its particular relevance for T-bet-expressing Th1 cells, strongly pointing to a supportive role of CXCR3 engagement during the adaptive immune system-mediated tumor control [31]. The gene discussed is FOXP3; the disease is colorectal carcinoma.