Finally, results from the same preclinical models interestingly suggested that the tumor micromilieu is able to further increase the TGFβ responsiveness of colon tumor-infiltrating CD4+ T cells by suppressing their expression of the TGFβ signaling-regulator Smurf2, with the consecutive induction of TGFβ receptor type II levels [142]. Here, TGFB1 is linked to colonic neoplasm.