Although human colon cancer tissue characterized by high expression levels of CXCL16 showed increased infiltration by CD4+ and CD8+ lymphocytes, data acquired in an experimental in vivo model of CRC metastasis interestingly indicated the particular relevance of the CXCL16/CXCR6-driven NKT cell recruitment for the control of hepatic CRC metastasis, while the beneficial effect of CXCL16 in this context seemed to be mostly independent of the presence or absence of CD8+ T cells [42]. This evidence concerns the gene CXCR6 and malignant colon neoplasm.