However, in contrast to its ligands, CXCL9, CXCL10, and CXCL11, the protein expression of the CXCR3 chemokine receptor protein in colon cancer tissue could be associated with increased tumor size, the occurrence of lymph node or distant metastasis, and poor survival [28]. Here, CXCL9 is linked to malignant colon neoplasm.