However, it should also be considered that the T cell-specific blockade of TGFβ-signaling in the AOM/DSS model of colitis-associated cancer resulted in enhanced tumor formation [93], which was obviously driven by the increased intratumoral presence of T cell-released IL-6 and its capacity to trigger the growth of dysplastic epithelial cells. Here, TGFB1 is linked to neoplasm.