CXCR4 and neoplasm: For instance, high expression levels of CXCR3, CXCR4, and CCL20 could be identified as a predictor of poor prognosis [26,27,28,29], while increased levels of CXCL16, CCL4, CX3CL1, CXCR6, CX3CR1, and CCR5 in CRC lesions turned out to indicate prolonged disease-free survival and were mostly associated with the profound accumulation of effector T cells in the tumor [4,21,30,31,32,33] (Figure 1).