IFNG and colonic neoplasm: Accordingly, the presence of Th1 cells, NK cells, and CD8+ T cells, as the main cellular producers of the pro-inflammatory cytokine IFNγ, in colon tumors correlates with improved clinical prognosis [5,65,66], while downregulation of the IFNR1 chain of type I interferon on the protein level in the cancer cell compartment or the stromal cell compartment of CRC tumors was found to be associated with poor disease prognosis [67].