MADCAM1 and malignant colon neoplasm: The increased intratumoral presence of integrin β7-postive cells was found to be associated with enhanced immune cell-mediated cytolytic activity and the improved survival of CRC patients [150], while another study described that decreased expression levels of MAdCAM-1, the ligand of α4β7, in human colon cancer tissue pointed to an improved colon tumor prognosis [151].