Analyses in the murine MC38 colon cancer model clearly indicated that the inhibition of the local IFN signaling via degradation of IFNAR1 resulted in the significantly decreased survival of tumor-infiltrating CD8+ T cells as the key cytolytic mediators of the immunological tumor control, and in the subsequent downregulation of cytolytic effector genes such as granzyme B and IFNγ [67]. The gene discussed is CD8A; the disease is neoplasm.