In accordance with its prognostically negative role, experimental silencing of IL-10 secretion in the local environment of MC38 tumors was able to inhibit tumor growth and to improve the efficacy of combined chemoimmunotherapy by reducing the local accumulation of myeloid-derived suppressor cells and Treg cells and by triggering Th1-mediated antitumor immunity [83,84]. Here, IL10 is linked to neoplasm.