IL10 and polyp of large intestine: As one of the cytokines integrally involved in the formation of an immunosuppressive tumor micromilieu, IL-10 was found to be markedly upregulated on the mRNA level in CRC-infiltrating Treg cells compared to colorectal polyps and control colon tissue derived from healthy volunteers, and increased serum levels of IL-10 could be linked to therapy failure, decreased survival, and post-surgical disease recurrence in CRC patients [79,80,81,82].