Several chemokines (e.g., CCL1, CCL3, CCL4, CCL7, CCL20, CCL25, CCL26, CX3CL1, CXCL1, CXCL8, CXCL9, CXCL10, and CXCL16) and partly also their respective G protein-coupled receptors (e.g., CCR1, CCR5, CCR6, CCR8, CXCR2, CXCR6, and CX3CR1) were found to be upregulated or selectively expressed in human colon cancer tissue compared to corresponding non-tumor control tissue [20,21,22,23,24,25]. This evidence concerns the gene CXCR6 and malignant colon neoplasm.