IFNG and neoplasm: Rather, CRC-infiltrating Th17 cells showed some Smad7-induced plasticity towards T-bet/RORγt double-positive T cells characterized by low IL-17A and increased IFNγ expression [77] and could in general be described as multifunctional modulators of the local antitumor immune response, which are able to secrete a broad spectrum of different cytokines and chemokines in addition to IL-17 and, thereby, to support also important mechanisms of tumor defense [75].