IL6 and colorectal carcinoma: The suggested unbeneficial influence of IL-6 on the fate of CRC disease was mainly attributed to its inhibitory effects on T cell-mediated aspects of antitumor immunity, as well as to its proliferative and anti-apoptotic effects on colon tumor cells, which are mainly mediated via the soluble IL-6 receptor (sIL6R) and IL-6 trans-signaling [93,96].