As another chemokine typically expressed in the intestinal mucosa and usually upregulated in colorectal cancer tissue, CCL4 (previously known as macrophage inflammatory protein (MIP)-1β) is mainly produced by hematopoietic cells and, besides mediating the chemoattraction of macrophages and NK cells, also promotes the intestinal recruitment of T cells via its receptor CCR5 [45,46,47]. This evidence concerns the gene CCL4 and colorectal cancer.