Interestingly, a successful therapeutic response to local IL-12 therapy in a model of hepatic colon cancer metastasis was associated with increased expression of the IL-15 receptor alpha (IL15Ra) in tumor-specific CD8+ T cells, indicating the significant relevance of IL-12 for IL-15-supported long-lasting memory CD8+ T cell responses [111]. The gene discussed is CD8A; the disease is neoplasm.