Adipokines and inflammatory cytokines secreted by adipose tissue play a vital role in regulating pathways, such as Janus kinase/signal transducer and activator of transcription (Stat) signaling, phosphoinositide 3-kinases/ AKT Serine/Threonine Kinase (PI3K/Akt) and mitogen-activated protein kinase/ Mitogen-Activated Protein Kinase 1 (MAPK/ERK), which promote cancer cell survival, and proliferation [38,39,40,41]. This evidence concerns the gene MAPK1 and cancer.