APP and Alzheimer disease: It was found that α-secretase processing of APP, which reduces Aβ formation is stimulated in DHA-treated cellular models of AD, including neuroblastoma cells overexpressing APP695wildtype or APP695 with the Swedish double mutation (K670N, M671L) or both the Swedish and the Arctic (E693G) mutations as well as APP695 transfected HEK cells [83,84,85].