NDUFA4L2 seemingly plays an important role within the process of ccRCC bioenergetic metabolic reprogramming (i.e., preferential activation of the pentose phosphate pathway, and impairment of mitochondrial activity), while also being involved in various other fundamental cellular processes (proliferation, migration and angiogenesis). Here, COXFA4L2 is linked to nonpapillary renal cell carcinoma.