SPORADIC:May present numerous molecular anomalies (both mono- and polysomies) of chromosomes 1, 2, 6, 9, 10, 13, 17, 21, and 22. Lack of mutations in the VHL, c-kit, PDGFRA, and FLCN genes.FAMILIAL:May be associated with BHD, autosomal dominant syndrome, characterized by a genetic abnormality on chromosome 17p11.2, leading to a mutation in the FLCN gene. Here, VHL is linked to Birt-Hogg-Dube syndrome.