Comparative analysis of these significantly mutated gene clusters within conventional RCC subtypes showed that only TP53 and PTEN (phosphatase and tensin homolog) mutations were encountered ubiquitously, in all conventional RCCs evaluated (ccRCC/pRCC/chRCC), yet prognostic value remained RCC subtype-specific. This evidence concerns the gene PTEN and nonpapillary renal cell carcinoma.