VHL and renal cell carcinoma: Additionally, each individual conventional RCC subtype (ccRCC, pRCC, and chRCC) has shown specific significantly mutated gene clusters comprised of RCC signature gene mutations (VHL/PBRM1), together with other recurrent mutations in non-specific genes, i.e., SETD2, KDM5C, PTEN, BAP1, MTOR, and TP53 [81], which apparently hold some predictive value regarding RCC prognosis.