Comparative genomic microarray and FISH studies reveal gains and losses of multiple chromosomes. Gains of sex chromosomes and gains of 3, 7, 16, 17, with a high prevalence of gains of Y, 3 and 16, distinguishing ACDA RCC from pRCC, which also has gains in chromosomes 7 and 17.VHL gene alterations. Chromosome 3p deletion. Here, VHL is linked to renal cell carcinoma.