ccRCC: CAIX(+, diffuse membranous), CK7(−), CD117(−), Cathepsin-K(−), HMB-45(−)ccPRCC: CAIX(+, cup-like pattern), CK7(+), CD117(−), Cathepsin-K(−), HMB-45(−)classic chRCC: CAIX(−), CK7(+, cytoplasmic), CD117(+, membranous), Cathepsin-K(−), HMB-45(−)eAML: CAIX(−), CK7(−), CD117(−), Cathepsin-K(+, cytoplasmic), HMB-45(+, cytoplasmic)MiT-TFE RCC:- Xp11/TFE3: CAIX(+/−, focal), CK7(−), CD117(+/−), Cathepsin-K (+, 50%, cytoplasmic), HMB-45(−)- t[6;11]/TFEB: CAIX(+/−, focal), CK7(−), CD117(−), Cathepsin-K(+, cytoplasmic), HMB-45(+, focal). The gene discussed is CTSK; the disease is nonpapillary renal cell carcinoma.