PDGFRA and gastrointestinal stromal tumor: Gastrointestinal stromal tumors (GIST) are rare sarcoma subtypes [1,2,3] likely arising from the interstitial cells of Cajal [4] after mutations to the c-kit gene affecting the tyrosine kinase receptor [5] or the platelet-derived growth factor receptor alpha (PDGF-Rα) [6].