BUB3 was an independent prognostic indicator for cancer-specific survival in human OSCC [16] and also showed an independent prognostic value in prostate cancer for the dichotomized scores of cytoplasmic BUB3, CCNB1 (cyclin B1) and PTTG1 (pituitary tumor-transforming gene) in both univariable and multivariable analyses. This evidence concerns the gene BUB3 and Familial prostate cancer.