In the analysis of the association between BUBR1 and the clinical-pathological characteristics, a significant association was observed between a high expression (extent score) of BUBR1 and breed (p = 0.03) (higher in large breeds), histological type (p = 0.029) (higher in conventional SCC), presence of bone invasion (p = 0.029), stage of invasion (p = 0.029) (higher in stage III) and advanced tumor stage (p = 0.034). This evidence concerns the gene BUB1B and neoplasm.