Visible changes of milk and mammary glands in clinical mastitis goats were presented and easy to check [24,38]; the breast function was impaired seriously, especially in gMECs, which proved that this can induce the expression and secretion of S100A7 and collapsed alveolus of mastitis goat glands [24]; therefore, it is normal that S100A7 abundance in clinical mastitis milk was decreased, due to the serious damage of the gMECs function. This evidence concerns the gene S100A7 and mastitis.