NR4A1 and Ureteral obstruction: In this study, we will investigate the effect of YHTR on kidney of unilateral ureteral obstruction (UUO) rat model, to determine the NR4A1 role in association with the pro-mitochondrial function which will further deepen the understanding of the pathophysiology of CKD and provide new ideas for the treatment of CKD using the YHTR.