NR4A1 and chronic kidney disease: 2014). UUO is a widely used model for the study of obstructive nephropathy, which causes the development of CKD (Chevalier et al. 2010). The present study successfully replicated the characteristics of CKD in UUO rat model, as evidenced by decreased renal function and impaired renal structure. Our data showed that YHTR improved renal function and ameliorated pathological renal injury via promoting NR4A1 expression, which regulating mitochondrial energy metabolism and mitochondrial function in UUO rats (Figure 7).