2016). Recent studies reported that NR4A1 can ameliorate age-related renal tubulointerstitial fibrosis by suppressing the TGF-β/Smads signalling pathway in myofibroblasts, suggesting that NR4A1 is a potential therapeutic target for age-related kidney diseases including CKD (Ma et al. 2022). NR4A1 is closely related to mitochondrial function. NR4A1 promotes glucose uptake, glycolysis, phosphoglycerol shuttle, and glycogenolysis (Pei et al. 2006; Chao et al. 2007). This evidence concerns the gene TGFB1 and chronic kidney disease.