KRAS and cancer: The Ras family of oncoproteins has beenstudied extensively for almost three decades, as activation of Rasrepresents a key feature of malignant transformation for many cancers.In the cancers that contribute most heavily to worldwide mortality,Ras mutations are extremely common.3 Severalisoforms of Ras exist, which are implicated in different types ofcancer.2,3 A member of this family, KRas-4B, is oftenfound in common and life-threatening cancers, such as lung cancer,colon cancer, and pancreatic cancer.3