TNF and neoplasm: Through recognition of distinct tumor-associated molecular markers as well as facilitation by other leukocytes, eosinophils degranulate and subsequently release TNF-α, granzymes, major essential protein (MBP), and metalloproteinases with a wide catch-net of effects involving recruitment of other leukocytes, antigen presentation to T cells, and tumor cell destruction.32 The release of ribonucleases and cationic proteins forms a cytotoxic extracellular trap driving tumor cell death.