Emphasizing the important role of ceramide in the modulation of tumorigenesis, recent studies by Ghosh et al. provided evidence that the application of exogenous C2 ceramide induces a strong anti-tumor response by increasing frequencies of cytotoxic CD8+ and IFN-γ-producing CD4+ T cells (Ghosh et al., 2020). The gene discussed is IFNG; the disease is neoplasm.