Recently,we applied ML in studies comprising hundreds of cerebrospinal fluid(CSF) or urine samples to predict the manifestation of neurodegenerativediseases.9,10 In these projects, established biomarkersassociated with the investigated diseases ranked among the top candidatessuch as tau, SOD1, and PARK7 in Alzheimer’s Disease (AD) andVGF and ENPEP in Parkinson’s Disease (PD), and potential novelones were uncovered. The gene discussed is MAPT; the disease is Parkinson disease.