To address the core challenges of NSCLC BM and drug resistance, Yin W et al. constructed a sophisticated liposomal system, T12/P-Lipo (126), in which they attached a transferrin receptor (TfR)-binding peptide T12 and an anti-PDL1 Nb to the surface of the liposome. This evidence concerns the gene CD274 and non-small cell lung carcinoma.