FFAR2 and colorectal carcinoma: Fusobacterium nucleatum colonization leads to increased intestinal short chain fatty acid (SCFA) levels and human CRC tissues harboring Fusobacterium nucleatum are primed to sense these immunomodulatory metabolites, with higher expression of the genes encoding the SCFA receptors FFAR2 and NIACR1. Furthermore, in Ffar2-/- mice, Fusobacterium nucleatum failed to increase Th17 cell frequency, suggesting that Fusobacterium nucleatum shaped Th17 response is FFAR2-dependent (32).