KRAS and intestinal cancer: showed that high fat diets (HFDs) resulted in changes in the composition of the gut microbiota (54), and in a Kras-driven mouse model of intestinal cancer, HFD-altered gut microbiome, which, in turn, resulted in reduced major histocompatibility complex (MHC) II expression on DCs and engages in immune evasion (55), suggesting that dietary in association with the gut microbiota, are critical modulators to the development of intestinal cancer.