TLR7 and infection: Additionally, our previously described IMDQ-PEG-Chol (TLR7/8 agonist) (26), was also found to elicit high HAI titers in 4 out of 6 animals, similar to unmodified IMDQ (Figure 2C-i), but with better lung virus control (Figure 2C-ii) five days post-infection when compared with unadjuvanted QIV or QIV with unmodified IMDQ.