During the progression of NAFLD, tissue-resident macrophages (MTRs) exhibit a different transcriptome, with higher expression of Trem2 and Cd9, and the apoptosis in MTRs is accelerated, while the loss of MTRs is compensated by infiltrating MDMs that exhibit characteristics similar to those of MTRs (26). The gene discussed is TREM2; the disease is metabolic dysfunction-associated steatotic liver disease.