SPP1 and Hepatic fibrosis: The expression of Fcgr2b and Spp1 (Figure 6B) was increased only in aggravated fatty liver, and the expression levels of Cxcl2 and Elane (Figures 6C, D) increased when liver fibrosis occurred which is not completely reversible, suggesting that these genes may play a key role in the prognosis of NAFLD.