In addition, mutations in NLRP1 result in constitutive NLRP1 inflammasome overactivation and inflammatory cytokines secretion, which have been associated with a number of chronic inflammatory disorders, including autoinflammation with arthritis and dyskeratosis (AIADK) and familial keratosis lichenoides chronica (FKLC) (12, 13). The gene discussed is NLRP1; the disease is arthritic joint disease.