Multivariate regression analysis demonstrated that TPD [odds ratio (OR): 4.36, 95% confidence interval (CI):1.37–13.90, p = 0.013] and hs-CRP (OR: 1.15, 95%CI: 1.02–1.30, p = 0.02) were independently related to the presence of CS (Table 2). This evidence concerns the gene CRP and Cowden syndrome 1.