In the univariate analysis, ALDH2*2 (OR: 2.321; 95% CI, (1.160, 4.648); P = 0.017) and hypertension (OR: 1.953; 95% CI, (1.011, 3.772); P = 0.046) were risk factors of persistent AF. This evidence concerns the gene ALDH2 and Hypertension.