This may be attributed to the delivery of TAU-ASOs starting at postnatal day 10, where cortical circuits may already be undergoing maladaptive remodeling.7 Importantly, disease phenotype reversibility is achievable after symptom onset through restoration of Nav1.1 function10 and may represent a more translatable treatment considering DS patients don’t exhibit any major symptoms before a first febrile seizure. Here, SCN1A is linked to Dravet syndrome.