Considering that epilepsies and tauopathies are emerging as two closely related pathologies, Shao and colleagues support a growing dogma that endogenous TAU may be modulated to decrease hyperexcitability in pathologies without a direct TAU implication.2, , , -6 In this case, TAU reduction decreases the excitability of excitatory neurons without any direct effect on the Nav1.1 loss affecting inhibitory neurons. The gene discussed is SCN1A; the disease is epilepsy.