For instance, a tsRNA derived from tRNA-His-GTG, 5′-tiRNA-His-GTG has been found to directly binding the 3'-untranslated regions of LATS2 gene, which encoded the component of hippo signaling pathway, and suppressed cells proliferations and promoted cells apoptosis through regulating YAP protein activity in colorectal cancers [8]. Here, LATS2 is linked to colorectal cancer.