TP53 and neoplasm: For example, low cancer mortality rates in elephants (Proboscidean lineage) may be linked to 20 genomic copies of the gene TP53 (Abegglen et al., 2015; Sulak et al., 2016), a tumour suppressor responsible for apoptosis, senescence, and cell cycle arrest in the presence of damaged DNA (Kumari et al., 2014).