Loss of TFF3, AGR2 was linked to impaired mucus and increased susceptibility to dextran sodium sulfate-induced colitis (Mashimo et al., 1996; Park et al., 2009)., GC Piezo1-/- mice exhibited decreased expression of Mucin2, TFF3, AGR2, and thinner mucus layer, which was consistent with the decreased GC numbers. The gene discussed is PIEZO1; the disease is colitis.