Importantly, the IFN-sensitive genes included in autoimmunity signatures of RA,48 systemic lupus erythematosus49 and Sjögren’s syndrome50 (e.g., IRF7, GAS6, IFI35, IFITM2, ISG15, ISG20, ODF3B) were also downregulated (Figure 3I). The gene discussed is ISG15; the disease is rheumatoid arthritis.