Importantly, the IFN-sensitive genes included in autoimmunity signatures of RA,48 systemic lupus erythematosus49 and Sjögren’s syndrome50 (e.g., IRF7, GAS6, IFI35, IFITM2, ISG15, ISG20, ODF3B) were also downregulated (Figure 3I). Here, IFI35 is linked to rheumatoid arthritis.