For diagnosis, AD is known to have very distinct hallmarks represented in the intracellular neurofibrillary tangles (NFTs) containing the protein tau in a hyper-phosphorylated state and the extracellular plaques containing amyloid beta (Aβ).3–6 Regardless the distinctive diagnostic markers for AD, unfortunately, the causes behind AD are not quite understood up till now. This evidence concerns the gene MAPT and Alzheimer disease.